How the Cyclin Became a Cyclin
نویسندگان
چکیده
منابع مشابه
How the Cyclin Became a Cyclin Regulated Proteolysis in the Cell Cycle
issue concerning the cell cycle, and E3 complexes provide the key to regulated proteolysis. Two E3 complexes Houston, Texas 77030 were discovered through studies of cell cycle regulation: the cyclosome/anaphase-promoting complex (APC) and the SCF complex. One hundred years from now when the dust of the pres-Classes of Ubiquitination Substrates ent has long settled and the wizened eye of history...
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The anaphase-promoting complex/cyclosome (APC/C) is the ubiquitin ligase essential to mitosis, which ensures that specific proteins are degraded at specific times to control the order of mitotic events. The APC/C coactivator, Cdc20, is targeted by the spindle assembly checkpoint (SAC) to restrict APC/C activity until metaphase, yet early substrates, such as cyclin A, are degraded in the presenc...
متن کاملPhosphorylation of cyclin O, a novel cyclin family protein containing a cyclin-like domain, is involved in the activation of cyclin-dependent kinase 2
Cell cycles, ordered series of events modulating cell growth and division, are tightly regulated by complexes containing cyclin-dependent kinases (CDKs) and cyclins. Cyclin O is a novel cyclin family protein which interacts with CDK2. However, the molecular effects of cyclin O on the activity of CDK2 have not been fully evaluated. In this study, an interaction between cyclin O and CDK2 was iden...
متن کاملHow I became a biochemist.
It was a sunny September day in a Madrid that had started to grow after years of stagnation, when I entered a modern red brick building at the corner of Velázquez and Joaquín Costa streets. I had an appointment with someone unknown to me, but whom I had been told was an important enzymologist. I was far from imagining that the encounter with that person would determine my future scientific life...
متن کاملThe Hunt for Cyclin
It is 25 years since Tim Hunt discovered cyclin, the oscillating protein that drives activation of cyclin-dependent kinases and entry into mitosis (Evans et al., 1983).
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ژورنال
عنوان ژورنال: Cell
سال: 1999
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)80753-9